Cell Biology, Neurobiology and Biophysics
Cells are the fundamental building blocks of all living organisms. Our aim is to acquire novel insights into the structure and function of cells and to decipher the cellular basis for human disease such as cancer and neurological disorders. To achieve this goal we combine the latest methods and technologies in molecular biology, biochemistry, genetics and microscopy.
Research Groups
Our goal is to obtain a physical understanding of the mechanisms by which cells establish and maintain their precise shape and intracellular organization. We focus on the cytoskeleton.
All forms of life display a variety of active processes on different length scales. We develop biophysical descriptions to understand how these active processes mediate the flow of energy and matter to self-organize cellular order and function.
We aim at understanding how the fundamental mechanisms of cell division can control fate transitions, with a developmental and evolutionary perspective. We are particularly interested in the last step of cell division, abscission, which is the final cut between the sister cells.
The goal of our lab is to understand the molecular mechanisms by which organelles are organized within neurons, and how organelle organization and networking contributes to neuronal development and function.
Our goal is to understand the mechanisms that shape and organize neurons in vivo, using the C. elegans model system and advanced imaging techniques.
The primary goal of the lab is to understand how intracellular protein trafficking underlies neuronal development and function.
Our group aims to understand how axons generate and conduct electrical impulses by investigating the properties and functions of its axonal domains and the myelin sheaths.
We develop improved therapies that are directed to relevant molecular targets. We are currently focused on using nanobodies to render photodynamic therapy of cancer more selective.
Our research focuses on combining statistical signal and image processing with advanced data modeling, with a particular focus on motion analysis in biological systems. We strive to move from pure image processing and analysis to completely automated image/data understanding, based on machine learning and artificial intelligence.
We study various facets of extracellular vesicle biology; from biogenesis to function. We do so by combining the development of smart molecular tools and transparent zebrafish in vivo model systems with state-of-the-art (live) imaging techniques.
